 |
Indication & Dosage |
| |
| |
| Oral |
| MILD TO MODERATE HYPERTENSION, OEDEMA AND ASCITIS DUE TO CHF AND CIRRHOSIS, NEPHROTIC SYNDROME |
| Adult:
Furosemide 20mg spironolactone 50mg (tabs). 1-4 tabs/day. |
|
| |
|
| Precautions |
Concomitant use with ACE inhibitors, monitor fluids and electrolytes including changes in serum K levels. Dilutional hyponatraemia or even a true low-salt syndrome may develop. General anaesthesia. |
| |
|
Potentially Life-threatening
Adverse Drug Reactions |
Severe hyperkalaemia in patients with preexisting renal impairment or taking ACE inhibitors, agranulocytosis, cardiac arrhythmias. |
| |
|
| Adverse Drug Reactions |
Fluid and electrolyte imbalance, nausea, diarrhoea, blurred vision, headache, dizziness, hypotension, photosensitisation, hepatic dysfunction, hyperglycaemia and glycosuria, rarely bone marrow depression, gynaecomastia, hirsutism, hoarseness, menstrual irregularities, loss of libido, impotence. |
| |
|
| Interactions |
Aminoglycosides and ethacrynic acid (increased ototoxicity), tubocurazine, succinylcholine (effects enhanced). Sucralfate reduces effects of furosemide. Should be given 2 hr apart. NSAIDs reduce natriuretic and antihypertensive effects of furosemide. Corticosteroids may antagonise action. Digoxin levels may be increased. Warfarin effects may be reduced. |
| |
|
|
|
